ICCVAM’s LLNA report available
This article was originally published in The Rose Sheet
Executive Summary
11Report from scientific panel convened in late April by the International Coordinating Committee on the Validation of Alternative Methods to review murine local lymph node assay test is now available at the NICEATM/ICCVAM Web site; public comment is invited. LLNA test is used to determine if substances may cause allergic contact dermatitis. Panel greenlighted two nonradioactive versions of the LLNA, with certain limitations, and showed support for third method "contingent upon demonstration of adequate interlaboratory reproducibility ... and an audit to verify summary data submitted for review" (2"The Rose Sheet" May 18, 2009, In Brief). ICCVAM will consider report and public feedback before making recommendation to federal agencies, which could lead to further reduction of animal use in product safety testing. ICCVAM panel met May 19-21 to consider alternative methods for gauging the eye irritation potential of antimicrobial cleaning products and determined data insufficient to support the EpiOcular, Cytosensor Microphysiometer and bovine corneal opacity and permeability assays (3"The Rose Sheet" June 1, 2009, In Brief)