Viability Of Preservative MI Use Remains Unclear; CIR Tables Review
This article was originally published in The Rose Sheet
CIR may take counter position to Europe in determining that preservative methylisothiazolinone can safely be used in leave-on personal care products, panel members suggested during March 17-18 meeting in Washington D.C. Review of the ingredient is tabled until the panel receives new sensitization data.
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At its September meeting, the Cosmetic Ingredient Review Expert Panel concluded that hydroquinone and p-hydroxyanisole are safe in gel nail products when LED lights are used in the curing process, but advises use of protective measures when UV lights, or fluorescent lights, are used due to concerns about skin-cancer risks. Separately, panel members issued a final amended assessment for preservative methylisothiazolinone, affirming their earlier tentative decision on the ingredient’s safety in rinse-off and leave-in products.
CIR’s Expert Panel recommends a limit of 4 ppm for preservative methylisothiazolinone in leave-on cosmetic products and 100 ppm in rinse-off formulas at a June 9-10 meeting in Washington, drawing from QRA data supplied by Cosmetics Europe. While CIR is still reviewing the Quantitative Risk Assessment for MI in various product categories, the panel decided to issue an assessment now, as the regulatory fate of the ingredient hangs in the balance in the EU.